Mary&May 2000 Shot Spicule Retinol PDRN Cream is an intensive night treatment designed to improve the appearance of enlarged pores, uneven texture, fine lines and loss of firmness. The formula combines approximately 200,000 marine micro-spicules with 1000 ppm Nano Liposome Retinol to support skin renewal and smoother-looking texture. Cica PDRN, including Sodium DNA and Centella Asiatica, provides soothing and conditioning care to help maintain skin comfort during active retinol treatment. The formula is further enriched with 2% Panthenol, Ceramide NP, Hyaluronic Acid and Allantoin to provide hydration and support the skin barrier. A mild to moderate tingling sensation may occur during application due to the micro-spicules. Dermatologist tested and suitable for gradual introduction into an evening skincare routine.