Doppelherz® aktiv KalD3 Tablets constitute the ideal combination to reach recommended daily intake of Calcium and ensure an optimal Calcium integration into the bones. Several factors can negatively influence circulating Calcium levels: unbalanced diets, age, lactation, menopause, use of glucocorticoids as well as of laxative. A small portion of Calcium is also naturally excreted in the urine. To compensate for decreasing blood Calcium levels, bone is degraded to release Calcium. This is why a constant supply of Calcium through the diet is primordial. Calcium is the most abundant mineral in the human body: it represents 1 to 2 % of our bodyweight (1 to 1.5 kg) found at 99 % in the bones and the teeth. Besides its obvious function in the structure and the robustness of these tissues, Calcium is also involved in muscle contraction, neurons activity and blood coagulation. Not only the total amount of ingested Calcium is important to keep strong bones, muscles and nerves: from the food to the bones, Calcium follows a complex path. Without the help of two vitamins this would not even be possible. From the food to the blood: dietary Calcium is absorbed at the level of the intestine, by a specific transporter which is stimulated by Vitamin D3. This vitamin is further on responsible for the blood balance of Calcium and Phosphate meant for bone formation. From the blood to the bone: circulating Calcium is brought to the bone matrix by proteins like osteocalcin. This is possible only if osteocalcin has been activated through a reaction dependent on Vitamin K. The right combination! The Calcium, Vitamin D3 and Vitamin K present in Doppelherz® aktiv KalD3 tablets constitute the ideal combination to reach Calcium recommended daily intakes and ensure an optimal Calcium integration into the bones.